In Cocktail Brain, players are confronted with a mixture of colorful liquids and their corresponding spheres. They need to mix the liquids to change the color of the spheres, with the aim of clearing the screen of every color. Clusters of spheres can be combined by getting the balls in close proximity with each other.
The player can rotate the view vertically and horizontally to strategically position the liquids. The liquids change color when combined, and new ones can be added from the top of the screen. The key is to mix the liquids to transform the balls to the desired hue by reacting them together. The result of the fluid reactions will allow for further color combinations.
The game progresses through different levels and requires a combination of mixing skills and strategy to achieve the objective. It runs in the browser without need for download or registration, making it easily accessible from any device. The ultimate challenge lies in efficiently clearing the screen of every color within the given timeframe.